DNA Rejuvenation & Repair

  • This is cutting edge area of HBOT research and they are still finding out new exciting mechanism about how HBOT works for DNA repair. So far the main theory is that HIF (hypoxic induced factor) plays the primary role in creating a cascade of cellular regeneration responses in th body and the the DNA is targeting based of their mechanism.

  • Most research applications of HBOT for DNA repair have shown that 60 sessions are needed to promote the biological cellular regeneration responses needed to rejuvenation DNA. Improvements continue to happen for many months after the course of treatment has ended.

  • Damage to DNA and negative changes to gene expression are primary mechanisms of aging according to modern research. HBOT has been shown to have a positive effect on both of these.

Research on HBOT for DNA Repair

The first scientific research on hyperbaric oxygen therapy (HBOT) dates back to the late 19th and early 20th centuries, but it wasn’t until recently that its effects on DNA came into focus. A remarkable study was published in the journal of Aging in 2020 that began to bring the concept of telomere length reduction into focus for HBOT researchers. Since then a number of other studies have shown HBOT to have a positive effect of not only telomere length, but also gene expression.

Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells: a prospective trial

Aging, Nov. 2020

Yafit Hachmo, Amir Hadanny, Ramzia Abu Hamed, Malka Daniel-Kotovsky, Merav Catalogna, Gregory Fishley, Erez Lang, Nir Polak, Keren Doenyas, Mony Friedman, Yonatan Zemel, Yair Becher, and Shai Efrati

This study showed that HBOT can achieve something that so far no other medical therapy has been able to do, significantly increase DNA telomere length. In this trial, HBOT therapy actually extended the length of telomeres by up to 37%, which is very significant. Telomere length protects our chromosomes from the damage that leads to aging. Low telomere length is with all the hallmark signs of aging as well as different diseases, low physical performance and cortical thinning of the brain. By increasing telomere length, we are able to literally add years of youth and vitality to our lives.

Hyperbaric oxygen therapy induces transcriptome changes in elderly: a prospective trial

Aging, Nov. 2021

Amir Hadanny, Relly Forer Dina Volodarsky , Malka Daniel-Kotovsky, Merav Catalogna, Yonatan Zemel, Yair Becher, and Shai Efrati

This study showed direct evidence that HBOT can induce positive gene-expression changes in whole-blood samples. Gene expression (transcriptome) is one of the scientific markers of aging. Transcriptional changes related to aging have been fond to correlate with inflammation, oxidative stress, mitochondrial and lysosomal degradation. These gene expression changes lead to cellular aging and increased susceptibility to diseases. In this study many gene expression changes associated with aging were found to significantly reverse following a course of 60 HBOT sessions.

The effect of hyperbaric oxygen therapy on cognition, performance, proteomics, and telomere length—The difference between zero and one: A case report

Frontiers Neurology, July 2022

Joseph C. Maroon

The author of this case report carried out a self-experiment to obtain objective information on the effects of HBOT therapy on neurocognition, cardiopulmonary function, neuroimaging and its effect on novel biomarkers such as telomere length and proteomics. After undergoing 60 HBOT sessions, his findings as published in this report showed improvements in global cognitive function, increased blood flow to many areas of the brain, improvements in endurance, strength, and a dramatic increase in telomere length.